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Buffalo Bills (AFC East)
| Year | Week | Location | Winner | Saints | Opponent | Tiebreaker | Saints | Opponent | |
|---|---|---|---|---|---|---|---|---|---|
| View Scores | 2021 | 12 | Home | Bills | 6 | 31 | Total Passing | 146 | 248 |
| View Scores | 2017 | 10 | Away | Saints | 47 | 10 | Total Rushing | 298 | 69 |
| View Scores | 2013 | 8 | Home | Saints | 35 | 17 | Total Offense | 299 | 386 |
| View Scores | 2009 | 3 | Away | Saints | 27 | 7 | Total Rushing | 222 | 89 |